Symbol
Name
ID

Ncf2
neutrophil cytosolic factor 2
MGI:97284

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes	Impaired oxidative burst	Granulomatosis	Elevated erythrocyte sedimentation rate	Splenomegaly
Disease(s) Associated with NCF2	Impaired oxidative burst	Granulomatosis	Elevated erythrocyte sedimentation rate	Splenomegaly
autosomal recessive chronic granulomatous disease 2
rheumatoid arthritis

Mouse Phenotypes

increased mean platelet volume

increased germinal center B cell number

increased follicular B cell number

increased B cell number

increased KLRG1-positive NK cell number

decreased NK cell number

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number

increased CD4-positive, alpha-beta memory T cell number

decreased CD8-positive, alpha-beta T cell number

increased CD8-positive, alpha-beta T cell number

decreased NK T cell number

decreased alpha-beta T cell number

decreased regulatory T cell number

decreased T cell number

increased T cell number

increased activated T cell number

decreased leukocyte cell number

abnormal spleen germinal center morphology

Availability

Mouse Genotype

Ncf2^{tm1a(EUCOMM)Wtsi}/Ncf2^{tm1a(EUCOMM)Wtsi}

Ncf2^{tm1b(EUCOMM)Wtsi}/Ncf2^{tm1b(EUCOMM)Wtsi}

Ncf2^{tm1b(EUCOMM)Wtsi}/Ncf2⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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